Results 241 to 250 of about 2,224,639 (290)

Bridging Chemical Literature and Molecular Graphs: LLM‐Augmented Enantioselectivity Prediction for Iridium‐Catalyzed Asymmetric C–H Borylation

Advanced Science, EarlyView.
A machine‐learning framework for asymmetric C–H borylation bridges multi‐entity 3D molecular graphs and chemical literature. Atom‐resolved mechanistic annotations extracted by large language models augment three‐component graph encoding of catalyst, substrate, and product. The model predicts enantioselectivity with high accuracy on unseen scaffolds and
Zhe Wang, Baohua Zhang, Yi Isaac Yang, Yuan Yao, Yinwu Li   +4 more
wiley   +1 more source

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

Advanced Science, EarlyView.
Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.
Chunya Ji, Yan Fang, Shen Zhang, Weichen Xu, Wenyun Guo, Jing Chen, Mingrui Zhu, Congjian Wen, Siming Chen, Yuli Zhu, Huixiong Xu, Haohao Yin   +11 more
wiley   +1 more source

Advancing Health Equity through 'One World for Health': Insights from the Seventy-Eighth World Health Assembly. [PDF]

Health Promot Perspect
Singh B, Chattu VK.
europepmc   +1 more source

Bacteria‐Derived 1‐Allylpiperazine Alleviates Symptoms of Parkinson's Disease Model by Promoting Autophagy

Advanced Science, EarlyView.
Parkinson's disease currently has no disease‐modifying therapies. In Caenorhabditis elegans, Escherichia coli E8 alleviates α‐synuclein‐provoked PD‐related defects through its bioactive metabolite 1‐ALPP, which combats PD by triggering AMPK/mTOR/HLH‐30‐dependent autophagy and suppressing α‐synuclein LLPS‐mediated fibrillization.
Mingqin Qu, Xinyuan Zhang, Xinyi Chen, Jiaxin Shi, Meng Xu, Fuhao Wang, Jinling Lv, Jiaman Sun, Weiyi Niu, Zihan Liu, Li Li, Fufeng Liu, Xiangming Wang   +12 more
wiley   +1 more source

Iran's great scientific divergence: The Middle-Income trap and the Political Economy of Science Policy. [PDF]

PLoS One
Roohi E.
europepmc   +1 more source

Credible capacity evaluation of virtual power plants considering wind and PV uncertainties. [PDF]

Sci Rep
Li C, Dai J, Zhu S, Guo R, Liu Z, Jiang Y, Tian S, Wen Y.   +7 more
europepmc   +1 more source

Postoperative Opioid-Free Multistep Opiranserin Infusion Versus Fentanyl Patient-Controlled Analgesia After Breast or Minimally Invasive Gynecologic Surgery: A Retrospective Cohort Study. [PDF]

J Clin Med
Kim Y, Park M, Choi S, Kim J, Kim J, Kim Y, Lee S, Noh C, Park J.   +8 more
europepmc   +1 more source

Estimating the future UK consultant physician workforce in relation to projected demand on the National Health Service: a modelling study. [PDF]

Lancet Reg Health Eur
Srinivasa A, Lovibond K, Carter E, Phillips C, Newbery N, Trudgill N.   +5 more
europepmc   +1 more source

Dietary Arginine Sets the Pace of MHC Class I Translation: A Nutrient Lever on Tumour Immunogenicity. [PDF]

MedComm (2020)
Asim M.
europepmc   +1 more source