Results 281 to 290 of about 2,746,744 (357)

Cost-effectiveness of Left Ventricular Assist Devices (LVADs) as destination therapy in the UK: An economic modelling study. [PDF]

PLoS One
Saygın Avşar T, Jackson L, Barton P, Beese S, Lim HS, Quinn D, Price M, Moor DJ.   +7 more
europepmc   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

A mining reality check on net zero. [PDF]

Nat Commun
europepmc   +1 more source

Coronary artery calcium on lung cancer screening-CT: An opportunity to optimize cardiovascular disease risk reduction. [PDF]

Int J Cardiol Heart Vasc
Mengesha B, Kasuku KM, Small TD, Caires MC, Garuba H, Law A, Johnson C, Paterson DI, Dennie C, Pena E, Chow BJ, Small GR.   +11 more
europepmc   +1 more source

A Yolk@Shell Photothermal Structure for Integrated Solar‐Driven Undrinkable Water Purification and Thermoelectric Power Generation

Advanced Science, EarlyView.
A yolk@shell structured photothermal evaporator was prepared via simple sol‐gel and spray coating methods. By taking advantage of the unique yolk@shell structure, the position of the TE module within the evaporator can be optimized without affects its water evaporation performance. This results in efficient and stable evaporation (3.08‐3.17 kg m−2 h−1)‐
Minrui Zhan, Xiang Fu, Yumei He, Manman Zhao, Xi Zhang, Rong Liu, Haonan Yang, Ming Yang, Huiyu Yang, Pei Lyu, Jiehao Du, Shaojin Gu, Xin Liu, Bin Shang   +13 more
wiley   +1 more source

Estimated blood storage requirements for a North Korean invasion of South Korea and South Korea's preparedness. [PDF]

J Trauma Inj
Hwang K, Park CY.
europepmc   +1 more source

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

Current and Projected Future Supply and Demand for Physical Therapists From 2022 to 2037: A New Approach Using Microsimulation.

Phys Ther
Zarek P, Ruttinger C, Armstrong D, Chakrabarti R, Hess DR, Manal TJ, Dall TM.   +6 more
europepmc   +1 more source