Results 91 to 100 of about 662,376 (305)

Rationality and dynamic consistency under risk and uncertainty [PDF]

, 2013
For choice with deterministic consequences, the standard rationality hypothesis is ordinality - i.e., maximization of a weak preference ordering. For choice under risk (resp.
Hammond, Peter J., Zank, Horst
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Investigating the Functional Utility of the Left Parietal ERP Old/New Effect: Brain Activity Predicts within But Not between Participant Variance in Episodic Recollection

Frontiers in Human Neuroscience, 2017
A success story within neuroimaging has been the discovery of distinct neural correlates of episodic retrieval, providing insight into the processes that support memory for past life events.
Catherine A. MacLeod, David I. Donaldson
doaj   +1 more source

Utility and Rationality in Neoclassical Economics: A Grangean Interpretation of the Theory of Expected Utility and of the Rational Expectations Hypothesis

Journal of Modern and Contemporary Philosophy, 2020
Utility theory is the foundations of the marginalism that grounds neoclassical economics. From its inception, in the 1870’s, it’s been through many transformations: it began as hedonistic (Jevons), acquired ordinalist features (Pareto), radicalized by mid-twentieth century, reaquired some cardinalist properties (von Neumann and Morgenstern) and became ...
openaire   +2 more sources

Asymmetric loss utility: an analysis of decision under risk [PDF]

This paper develops a utility model for evaluating lotteries. In estimating utility, risk averse people use an asymmetric loss function. Expected utility is seen as a special case that is a good approximation of the general case in some cases.
Alex Strashny
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Contingent Claim Pricing In A Dual Expected Utility Theory Framework [PDF]

This paper investigates the price for contingent claims in a dual expected utility theory framework, the dual price, considering complete arbitrage-free nancial markets.
Andrea Gheno, Massimiliano Corradini
core  

Diversification and Endogenous Financial Networks [PDF]

, 2015
We test the hypothesis that interconnections across financial institutions can be explained by a diversification motive. This idea stems from the empirical evidence of the existence of long-term exposures that cannot be explained by a liquidity motive ...
Héam, Jean-Cyprien, Koch, Erwan
core  

Quantum Structure in Economics: The Ellsberg Paradox

, 2012
The 'expected utility hypothesis' and 'Savage's Sure-Thing Principle' are violated in real life decisions, as shown by the 'Allais' and 'Ellsberg paradoxes'. The popular explanation in terms of 'ambiguity aversion' is not completely accepted.
Aerts, Diederik, Sozzo, Sandro
core   +1 more source