Results 41 to 50 of about 1,453,138 (305)
The Loss-Averse Retailer’s Order Decisions Under Risk Management
Mathematics, 2019 This paper characterizes the retailer’s loss aversion by introducing a loss aversion coefficient and proposes a new loss aversion utility function for the retailer.
Felix T. S. Chan, Xinsheng Xu
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Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa +3 more
wiley +1 more source
UUV Autonomous Decision-Making Method Based on Dynamic Influence Diagram
Complexity, 2020 Considering the complexity and uncertainty of decision-making in the operating environment of an unmanned underwater vehicle (UUV), this study proposes an autonomous decision-making method based on the dynamic influence diagram (DID) and expected utility
Hongfei Yao, Hongjian Wang, Ying Wang
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Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A Bayesian Method for Characterizing Population Heterogeneity
Games, 2019 A stylized fact from laboratory experiments is that there is much heterogeneity in human behavior. We present and demonstrate a computationally practical non-parametric Bayesian method for characterizing this heterogeneity.
Dale O. Stahl
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Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Quantifying Risk Perception: The Entropy Decision Risk Model Utility (EDRM-U)
Systems, 2020 Risk perception can be quantified in measurable terms of risk aversion and sensitivity. While conducting research on the quantization of programmatic risk, a bridge between positive and normative decision theories was discovered through the application ...
Thomas Monroe +2 more
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Great Expectations: Cost-Utility Models as Decision Criteria
INNOVATIONS in pharmacy, 2016 One of the more puzzling features of published claims for cost-effectiveness is the popularity of claims presented in terms of quality adjusted life years (QALYs). Despite the popularity of QALYs as the ‘gold standard’ outcome measures among academic audiences, professional groups and a number of single payer health care systems, there is no evidence ...
openaire +3 more sources