Results 91 to 100 of about 3,270 (240)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Case opacity and Cliticization: On intervention and the triggers of different agreement patterns
Linguística, 2017 We will show that there are two types of languages which involve different mechanisms in obviating Minimality Violations/Defective Intervention and Case Opacity: Agreement languages of Punjabi/Icelandic-type with default agreement and Movement ...
Mihaela Marchis Moreno, Ludovico Franco
doaj
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Comprehension of Complex Structures by Persian-speaking Aphasics: The Role of Cognitive Load
Journal of Modern Rehabilitation, 2021 Introduction: So far, many studies have investigated the extent and nature of the grammatical deficit in aphasia. However, to the best of our knowledge, this research is the first in the Persian language to inspect the comprehension of patients with ...
Omid Azad
doaj
Experiencer-Specific Emotion and Appraisal Prediction
, 2023 Emotion classification in NLP assigns emotions to texts, such as sentences or paragraphs. With texts like "I felt guilty when he cried", focusing on the sentence level disregards the standpoint of each participant in the situation: the writer ("I") and ...
Wegge, Maximilian +3 more
core
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Psych nouns and adjectives, PPthemes and predication (or a leopard cannot change its spots)
Anuario del Seminario de Filología Vasca "Julio de Urquijo", 2018 Starting from Belleti Rizzi's (1988) work, there has been a great progress in the understanding of psych predicates, but not as much on the predication involving psych adjectives and nouns.
Beatriz Fernández, Ane Berro
doaj
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source