Results 141 to 150 of about 5,256,084 (284)
, 1950 35 p., Idaho Agricultural Experiment Station, Research Bulletin No.
Fireman, Milton; Mogen, C. A.; Baker, George Orien
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Genetic and Environmental Changes as shown by Idaho D.H.I.A. Records (034, Research Bulletin, 1956)
, 1956 16 p., Idaho Agricultural Experiment Station, Research Bulletin No.
Everson, Dale O.; Johnson, K. R.
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Experience of Experience by Experience
Abstract: This bachelor thesis uses the film Flee (Rasmussen, 2021) to study the dialog between me and the film, analyzed through a phenomenological perspective. Through an analysis of the narrative and visual traits of the film, which triggered my sensual experience connected to a shared trauma with the protagonist, I aim to figure out how my personal
openaire +1 more source
Better dairy methods (067, Bulletin No., 1909)
, 1909 48 p., University of Idaho Agricultural Experiment Station, Bulletin No.
Frandson, J.H.
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Annual report for year ending June 30, 1915 (084, Bulletin No., 1915)
, 1915 47 p., University of Idaho Agricultural Experiment Station, Bulletin No.
Brannon, M.A.; Jones, J. Shirley
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Canning fruits and vegetables on the farm (082, Bulletin No., 1915)
, 1915 24 p., University of Idaho Agricultural Experiment Station, Bulletin No.
Vincent, Clarence C.
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