Results 111 to 120 of about 9,261,944 (317)
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Films aún no conocidos en España [PDF]
Cine experimental (1945). Films aún no conocidos en España. Cine experimental. (5):310-310.
Cine experimental
core
The precise estimation of influential parameters in adsorption is a key point in conducting simulations for the sensitivity analysis and optimal design of cooling systems.
Maaed Ossman +2 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Atención a los desaprensivos. Desorientación
Cine experimental (1946). Atención a los desaprensivos. Desorientación. Cine experimental. (11):196-196.
Cine experimental
core
Editorial: Insights in veterinary experimental and diagnostic pathology: 2021
Francisco Javier Salguero
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The mountain of Tindaya (Fuerteventura, Canary Islands) has been entangled in controversy for over thirty years. The mountain is, at once, a sacred site for the indigenous people of Fuerteventura– who decorated it with hundreds of engravings–; a mining ...
Isaac Marrero Guillamón
doaj

