Results 281 to 290 of about 25,744,716 (381)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Molecular effects of digital psychological intervention for perinatal stress: cell culture, animal model validation, and machine learning-based biomarker identification. [PDF]

Sci Rep
Wang X, Zhong X.
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Artificial neural network as a strategy to predict rheological properties in emulgel formulations. [PDF]

Sci Rep
Duarte LS, Molano L, Jiménez RA, Guevara-Pulido J.   +3 more
europepmc   +1 more source

Numerical experimental study on combined support of bolt-arch in circular roadway

Ning Yang, Donghao Li, Mei‐Xia Zhao, Weiteng Li   +3 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Development and Experimental Validation of a Physics-Based Digital Twin for Railway Freight Wagon Monitoring. [PDF]

Sensors (Basel)
Cascino A, Nencioni L, Lanzillo L, Mazzeo F, Strano S, Terzo M, Delle Monache S, Meli E.   +7 more
europepmc   +1 more source

Local Transport Analysis of High-Beta Plasmas with γ = 1.20 [PDF]

Experimental Group LHD, H. Funaba, K.Y. Watanabe   +2 more
core  

Applied Design Research in Living Labs and Other Experimental Learning and Innovation Environments

Peter Joore, Anja Overdiek, Wina Smeenk, Koen van Turnhout   +3 more
openalex   +1 more source