Results 51 to 60 of about 8,813,891 (266)
Applied Sciences, 2023 The article presents the results of experiments aimed at finding the displacement of a cylinder being part of a boom system, as recorded after initiating a rapid breaking process.
Tomasz Siwulski
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Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Ground Truth in Classification Accuracy Assessment: Myth and Reality [PDF]
The ground reference dataset used in the assessment of classification accuracy is typically assumed implicitly to be perfect (i.e., 100% correct and representing ground truth).
Foody, Giles M., Giles M. Foody
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Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2011 Two experiments are reported that investigate the impact of misinformation on memory accuracy and metacognitive resolution. In Experiment 1, participants viewed a series of photographs depicting a crime scene, were exposed to misinformation that ...
Luna, K., Higham, P. A., Bloomfield, J.
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Categorizing coefficients of variation in sunflower trials
Crop Breeding and Applied Biotechnology, 2003 This study was carried out to categorize coefficients of variation (CV’s) associated with important traits of routine use in the sunflower breeding programs. Separate categories were obtained for the August/September and February/March sowings. Data were
Claudio Guilherme Portela de Carvalho +5 more
doaj
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source