Results 121 to 130 of about 821,446 (263)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Editorial: Dynamics and functional exploration of pharmacologically active proteins. [PDF]

Front Chem
Li Z, Bala C, Zhang L.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Aliasing Artifacts in Multielemental LA-ICP-TOFMS Mapping: An Old Problem Revisited. [PDF]

Anal Chem
Cernatič F, Mervič K, Schlatt L, Šala M.   +3 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Correction: Biodegradable Prussian blue/manganese dioxide core-shell nanoparticles with open cages for imaging-guided chemo-photothermal combined therapy of cancer cells. [PDF]

RSC Adv
Gao Y, Xue J, Yang Y, Bian D, Liu L, Zhu M, Yang T, Liu L.   +7 more
europepmc   +1 more source

Experimental Organic Chemistry [PDF]

Nature, 1921
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Rapid Replenishment of Phylloquinone in the Plasma and Liver Using Hyaluronan-Based Nanocapsules Reverses Endothelial Dysfunction in Mice

Nanotechnology, Science and Applications
Anna Kieronska-Rudek,1,2 Agnieszka Kij,1 Anna Bar,1 Magdalena Sternak,1 Aleksandra Paterek,3 Filip Rolski,3 Izabela Czyzynska-Cichon,1 Filip A Fedak,1,4 Kamila Wojnar-Lason,1,2 Justyna Bednorz,4,5 Małgorzata Janik-Hazuka,5 Renata B Kostogrys,6
Kieronska-Rudek A, Kij A, Bar A, Sternak M, Paterek A, Rolski F, Czyzynska-Cichon I, Fedak FA, Wojnar-Lason K, Bednorz J, Janik-Hazuka M, Kostogrys RB, Franczyk-Zarow M, Czyżowska KZ, Michalkova L, Mączewski M, Zapotoczny S, Kus E, Chlopicki S   +18 more
doaj  

Surface tension measurements reveal charge-driven surfactant depletion in microdroplets approaching the Rayleigh limit. [PDF]

Chem Sci
Ahmed F, Jacobs MI.
europepmc   +1 more source