Results 121 to 130 of about 824,899 (263)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Editorial: Dynamics and functional exploration of pharmacologically active proteins. [PDF]

Front Chem
Li Z, Bala C, Zhang L.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Rapid Replenishment of Phylloquinone in the Plasma and Liver Using Hyaluronan-Based Nanocapsules Reverses Endothelial Dysfunction in Mice

Nanotechnology, Science and Applications
Anna Kieronska-Rudek,1,2 Agnieszka Kij,1 Anna Bar,1 Magdalena Sternak,1 Aleksandra Paterek,3 Filip Rolski,3 Izabela Czyzynska-Cichon,1 Filip A Fedak,1,4 Kamila Wojnar-Lason,1,2 Justyna Bednorz,4,5 Małgorzata Janik-Hazuka,5 Renata B Kostogrys,6
Kieronska-Rudek A, Kij A, Bar A, Sternak M, Paterek A, Rolski F, Czyzynska-Cichon I, Fedak FA, Wojnar-Lason K, Bednorz J, Janik-Hazuka M, Kostogrys RB, Franczyk-Zarow M, Czyżowska KZ, Michalkova L, Mączewski M, Zapotoczny S, Kus E, Chlopicki S   +18 more
doaj  

Aliasing Artifacts in Multielemental LA-ICP-TOFMS Mapping: An Old Problem Revisited. [PDF]

Anal Chem
Cernatič F, Mervič K, Schlatt L, Šala M.   +3 more
europepmc   +1 more source

Experimental Organic Chemistry [PDF]

Nature, 1921
openaire   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Correction: Biodegradable Prussian blue/manganese dioxide core-shell nanoparticles with open cages for imaging-guided chemo-photothermal combined therapy of cancer cells. [PDF]

RSC Adv
Gao Y, Xue J, Yang Y, Bian D, Liu L, Zhu M, Yang T, Liu L.   +7 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Surface tension measurements reveal charge-driven surfactant depletion in microdroplets approaching the Rayleigh limit. [PDF]

Chem Sci
Ahmed F, Jacobs MI.
europepmc   +1 more source