Results 171 to 180 of about 2,596,240 (298)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Parallel but distinct adaptive routes in the budding and fission yeasts after 10,000 generations of experimental evolution. [PDF]

Nat Ecol Evol
N'Guessan A, Wang V, Bakerlee CW, Belousova J, Brenna GY, Dillingham ME, Gopalakrishnan S, Goyal J, Gupta M, Holmes CM, Humphrey PT, Jagdish T, Jerison ER, Johnson MS, Kosheleva K, Lawrence KR, Min J, Moulana A, Pai SV, Phillips AM, Piper JC, Purkanti R, Rego-Costa A, Ruiz-Bedoya T, Trivellin C, McDonald MJ, Desai MM, Nguyen Ba AN.   +27 more
europepmc   +1 more source

Experimental Evolution Poster Presentation

, 2019
Experimental evolution poster.
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Sex-allocation trade-offs and their genetic architecture revealed by experimental evolution. [PDF]

Proc Natl Acad Sci U S A
Gerchen JF, Villamil-Buenrostro N, Li X, Le Faou E, Pannell JR.   +4 more
europepmc   +1 more source

Unraveling the Molecular Basis of Stabilizing Selection by Experimental Evolution. [PDF]

Genome Biol Evol, 2023
Schlötterer C.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The adaptation chip: repurposing the principles of the ichip for guiding in situ experimental evolution. [PDF]

ISME Commun
Kaminsky LM, Sadeghi J, Grandinette E, Bell TH.   +3 more
europepmc   +1 more source

Experimental Biology and Evolution [PDF]

Evolution, 1954
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source