Results 241 to 250 of about 522,424 (297)

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

The "I" in egalitarianism: Hadza hunter-gatherers averse to inequality primarily when personally unfavorable. [PDF]

PNAS Nexus
Smith KM, Stibbard Hawkes DNE, Dimant E, Mabulla IA, Bicchieri C, Apicella CL.   +5 more
europepmc   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

The art and science of serious game design: a quasi-experimental study based on self-determination theory in traditional Chinese culture education. [PDF]

Front Psychol
Yang J, Li R.
europepmc   +1 more source

Bioenergy Cropping Reduces the Spatiotemporal Scaling of Soil Bacterial Biodiversity

Advanced Science, EarlyView.
Consistent with patterns observed in plant and animal communities, soil bacterial communities exhibit significant species–time–area and phylogenetic–time–area relationships independent of nested structure. Bioenergy cropping significantly reduces the spatiotemporal scaling rates, particularly in sandy loam soils.
Zhencheng Ye, Jialiang Kuang, Colin T. Bates, Arthur Escalas, Daliang Ning, Liyou Wu, Suo Liu, Sihang Deng, Jiesi Lei, Xiangwen Chen, Jennifer Pett‐Ridge, Malay Saha, Lauren Hale, Gangsheng Wang, Renmao Tian, Ying Fu, Yu Tang, Mary Firestone, Jizhong Zhou, Yunfeng Yang   +19 more
wiley   +1 more source

Analysis of Spatiotemporal Features in a Virtual Navigation Game Across Different Age Groups: Quantitative Research.

JMIR Serious Games
Qiao X, Tian S, Tang M, He S, Wang J, Fan L, Zhu Y, Zhang Z, Du S, Dong C, Chen Y, Liu X.   +11 more
europepmc   +1 more source

Physical activity intervention improves executive function in children with autism spectrum disorder: a meta-analysis. [PDF]

Front Pediatr
Li Y, Gao C, Song S.
europepmc   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

A Randomized Proof-of-Concept Study of Gamified Rhythmic Training in Autistic Children. [PDF]

Ann N Y Acad Sci
Jamey K, Laflamme H, Foster NEV, Rigoulot S, Hyde KL, Dalla Bella S.   +5 more
europepmc   +1 more source

Non-immersive virtual reality games, sleep, and sedentary behavior in children. [PDF]

Front Sports Act Living
Souza APDS, Lopes de Souza S, Dos Santos MERA, da Silva ABJ, da Silva KG, da Silva RF, da Silva JML, da Silva ML, da Silva ÉHA, Ferreira WWD, de Arruda PRL, Carneiro ACBDF, Barros WMA.   +12 more
europepmc   +1 more source