Results 161 to 170 of about 4,610,690 (301)

Experimental investigation of mechanical properties in cryogenically damaged shale. [PDF]

Sci Rep
Zheng X, Zhang G, Wang D, Yang F, Lu M, Song L, Zhou D.   +6 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Photophysical and Photochemical Properties of a Curcumins Family: A Combined Computational and Experimental Investigation. [PDF]

ACS Omega
Ghiami-Shomami A, Ruggieri S, Mizzoni S, Piccinelli F, Terenziani F, Pettinari R, Pagliaricci N, Pagliaricci S, Melchior A.   +8 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Experimental Investigation of the directional collapse and microjet dynamics of single acoustic bubbles in confined tubes. [PDF]

Ultrason Sonochem
Wu H, Zhang T, Fang Y, Yu R, Jin Y, Ohl CD, Li Y.   +6 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Editorial: What Are (Un)Acceptability and (Un)Grammaticality? How Do They Relate to One Another and to Interpretation?

Frontiers in Psychology, 2020
Susagna Tubau, Urtzi Etxeberria, Viviane Déprez, Viviane Déprez, M.Teresa Espinal   +4 more
doaj   +1 more source

Experimental investigation of factors affecting microbial liquefaction mitigation in coastal liquefied sand. [PDF]

Front Microbiol
Hu J, Liu M, Ren J, Li Y, Yuan H.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Experimental investigation of diffusion flames with different baffle-plate air-hole diameters. [PDF]

Sci Rep
Mohammed ES, Gad HM, Ibrahim IA, Habik SE, Elsakka MM.   +4 more
europepmc   +1 more source