Results 11 to 20 of about 4,610,690 (301)

Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors

Breast Cancer Research, 2022
Background PI3K signaling is frequently activated in breast cancer and is targeted by PI3K inhibitors. However, resistance of tumor cells to PI3K inhibition, often mediated by activated receptor tyrosine kinases, is commonly observed and reduces the ...
Guus J. J. E. Heynen, Kamil Lisek, Regina Vogel, Annika Wulf-Goldenberg, Joshua Alcaniz, Elodie Montaudon, Elisabetta Marangoni, Walter Birchmeier   +7 more
doaj   +1 more source

Numerical Experimental Investigation of Solidification Thickness around Cylindrical Surfaces for HVAC Cold Storage Systems [PDF]

, 2018
Thermal Ice Storage System (TISS) is an innovative way of storing night-time off-peak energy for daytime peak USAge. In many locations, demand for electrical power peaks during summer time. Air-conditioning equipment are the main reason accounting for as
Abbas, J. Y. (Jamal), Badran, B. E. (Bassam), Tina, H. A. (Hussein)   +2 more
core   +1 more source

Experimental Investigation of the Effects of Hydrogen Addition with Diesel on Performance and Emission of a Single Cylinder Diesel Engine [PDF]

, 2018
Need of the hour in present day scenario is to cope with energy crisis and human life in India and around the globe which is associated with depletion in the percentage of petroleum products and increase in the share of pollution caused due to emissions ...
Dubey, N. (Nitin), Hashmi, M. H. (Mirza)
core   +1 more source

Prolactina y galactorreas.

Acta Médica Portuguesa, 1979
Se expone el mecanismo de secreción de prolactina (PRL) con especial atención al efecto de la dopamina (DA) como agente neurotransmisor. El hecho que la secreción de PRL es modificada por medicamentos que actúan al nivel de los receptores de DA en el ...
Emílio del Pozo
doaj   +1 more source

Preclinical research in paclitaxel-induced neuropathic pain: a systematic review

Frontiers in Veterinary Science, 2023
IntroductionChemotherapy-induced peripheral neuropathy (CIPN) is a common consequence of cancer treatment and pain is a frequent complaint of the patients.
Carolina Bacalhau, José Tiago Costa-Pereira, José Tiago Costa-Pereira, José Tiago Costa-Pereira, Isaura Tavares, Isaura Tavares   +5 more
doaj   +1 more source

THE EXPERIMENTAL MODEL OF OSTEONECROSIS

Travmatologiâ i Ortopediâ Rossii, 2016
The experimental investigation for the purpose of modeling of knee osteonecrosis were performed in 36 rats. The chronic renal insufficiency by means of left nephrectomy and electrocoagulation in 25% cortical substance of right kidney was induced before 6
G. I. Netylko, M. Yu. Zaytseva
doaj   +1 more source

Antimalarial evaluation of alkyl-linked bis-thiadiazine derivatives in murine model infected with two Plasmodium strains

ADMET and DMPK, 2023
Background and Purpose: Plasmodium falciparum and P. vivax are responsible for most malaria cases in humans in the African Region and the Americas; these parasites have developed resistance to classic antimalarial drugs.
Katherine Stefania Loachamin Gualotuña, Lilian M. Spencer, Hortensia Maria Rodriguez Cabrera, Renata Abigail Montero Calderón, Beatriz Pernía, Julieta Coro, Margarita Suarez, Francisco Javier Tingo Jacome, Zully J. Rodriguez Parra, Jose Manuel Lozano, Jesús Cortés Vecino   +10 more
doaj   +1 more source

Experimental investigation of criteria for thermal roughening [PDF]

, 1995
The morphology of single domain Si(001)2 × 1 surfaces has been investigated with scanning tunneling microscopy (STM). Using the model of Villain, Grempel and Lapujoulade, which is based on the microscopic properties of the surface, this vicinal surface ...
Hegeman, Petra E., Kersten, Bart A.G., Kip, Gerard A.M., Poelsema, Bene, Zandvliet, Harold J.W.   +4 more
core   +4 more sources

An Experimental Investigation of Colonel Blotto Games [PDF]

, 2011
"This article examines behavior in the two-player, constant-sum Colonel Blotto game with asymmetric resources in which players maximize the expected number of battlefields won. The experimental results support all major theoretical predictions.
A. Botelho, A. Chau, A. Lizzeri, A. Lizzeri, B. Roberson, B.S.Y. Crutzen, C.A. Holt, C.F. Camerer, C.R. Price, D. Davis, D. Kovenock, D. Kreps, D. Kvasov, D. Strömberg, D.J. Clark, D.J. Clark, D.W. Blackett, D.W. Blackett, Dan Kovenock, J. Avrahami, J. Druckman, J. Parco, J.C. Potters, J.F. Laslier, J.F. Laslier, J.M. Snyder, J.W. Tukey, K. Hausken, L. Friedman, M. Shubik, M. Walker, N. Sahuguet, P. Klemperer, R. Bellman, R. Croson, R. Golman, R. Powell, R.B. Myerson, R.M. Sheremeta, R.M. Sheremeta, R.M. Sheremeta, Roman M. Sheremeta, S. Hart, S. Rosen, Subhasish M. Chowdhury, T. Klumpp, T.C. Schelling, U. Fischbacher, U. Gneezy, V. Lugovskyy, V.P. Crawford, W. Amaldoss, Y. Barut   +52 more
core   +5 more sources

Poly(I:C) Potentiates T Cell Immunity to a Dendritic Cell Targeted HIV-Multiepitope Vaccine

Frontiers in Immunology, 2019
Cellular immune responses are implicated in resistance to HIV and have been considered for the development of an effective vaccine. Despite their safety profile, subunit vaccines need to be delivered combined with an adjuvant.
Juliana de Souza Apostólico, Juliana de Souza Apostólico, Victória Alves Santos Lunardelli, Victória Alves Santos Lunardelli, Marcio Massao Yamamoto, Edecio Cunha-Neto, Edecio Cunha-Neto, Silvia Beatriz Boscardin, Silvia Beatriz Boscardin, Daniela Santoro Rosa, Daniela Santoro Rosa   +10 more
doaj   +1 more source