Results 111 to 120 of about 1,440,027 (252)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A Review of the Exhibition “Susan Glaspell (1876-1948): pionera del teatro experimental. Trifles, los Provincetown Players y el teatro de vanguardia” (“Susan Glaspell (1876-1948): The Pioneer of Experimental Theatre. Trifles, the Provincetown Players and the Avant-garde Theatre”)

Miranda: Revue Pluridisciplinaire du Monde Anglophone, 2017
Review of the Exhibition “Susan Glaspell (1876-1948): pionera del teatro experimental. Trifles, los Provincetown Players y el teatro de vanguardia” (“Susan Glaspell (1876-1948): The Pioneer of Experimental Theatre.
Quetzalina Lavalle Salvatori
doaj  

Feline Temporal Lobe Epilepsy: Review of the Experimental Literature. [PDF]

J Vet Intern Med, 2017
Kitz S, Thalhammer JG, Glantschnigg U, Wrzosek M, Klang A, Halasz P, Shouse MN, Pakozdy A.   +7 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Experimental Typography in Visual Design: A Systematic Literature Review

Art Vision
Experimental typography is a design approach that redefines the form and function of letters by overcoming the rules of traditional typography. The works in this approach offer new ways of expression by using various techniques and forms to increase the ...
Aysel Güney Türkeç, Feray Uğur Erdoğmuş   +1 more
doaj   +1 more source

The proximal effects of acute alcohol use on female aggression: A meta-analytic review of the experimental literature. [PDF]

Psychol Addict Behav, 2017
Crane CA, Licata ML, Schlauch RC, Testa M, Easton CJ.   +4 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Alcohol Use Predicts Sexual Decision-Making: A Systematic Review and Meta-Analysis of the Experimental Literature. [PDF]

AIDS Behav, 2016
Scott-Sheldon LA, Carey KB, Cunningham K, Johnson BT, Carey MP, MASH Research Team.   +5 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source