Results 191 to 200 of about 5,901,623 (279)

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Expressive pragmatic language in mood and psychotic disorders: a systematic review and meta-analysis. [PDF]

Schizophrenia (Heidelb)
Meister F, Sellier Silva M, Melshin G, El Mouslih C, Zaher F, Sattari R, Wei HT, Mekideche N, Bambini V, Voppel A, Palaniyappan L.   +10 more
europepmc   +1 more source

Ceftriaxone‐induced liver injury: Incidence, phenotypic characterization and predictive factors

British Journal of Clinical Pharmacology, EarlyView.
Introduction Ceftriaxone is a widely used third‐generation cephalosporin in hospitalized patients. Although generally considered safe, it has been associated with hepatobiliary complications and emerging reports of drug‐induced liver injury (DILI). However, data on its true incidence, phenotypic patterns, and predictors remain limited. This study aimed
Mohamed Hatem, Mohannad N. AbuHaweeleh, Humam Emad Rajha, Mhd Osama Rahhal, Ahmad Hamdan, Lina Naseralallah   +5 more
wiley   +1 more source

Ten years of using the APACS test: a multistudy cross-diagnostic analysis of pragmatic profiles and their relationship with Theory of Mind. [PDF]

Philos Trans R Soc Lond B Biol Sci
Frau F, Bosia M, Bischetti L, Cappelli G, Carotenuto A, Diamanti L, Montemurro S, Agostoni G, Bechi M, D'Imperio D, Lago S, Noccetti S, Simi N, Ceroni M, Iodice R, Signorini M, Arcara G, Bambini V.   +17 more
europepmc   +1 more source

Exposure to CYP2C19‐metabolized drugs following acute stroke: A longitudinal cohort study to inform implementation of CYP2C19 genotype testing

British Journal of Clinical Pharmacology, EarlyView.
Aims Cytochrome P450 2C19 (CYP2C19) genotype testing is recommended to guide antiplatelet selection after ischaemic stroke and transient ischaemic attack. CYP2C19 also metabolizes several commonly prescribed non‐antiplatelet drugs. We aimed to quantify exposure to CYP2C19‐metabolized drugs in stroke patients at hospital discharge and during ...
Cleodie C. Swire, Andrew T. Lambarth, Ayesha Saleem, Daniel R. Burrage   +3 more
wiley   +1 more source

From the First Tooth to the Intensive Care Unit: Diet, Gut Microbiota and Neuroinflammation Across the Life Course. [PDF]

Nutrients
Corriero A, Soloperto R, Preiser JC.
europepmc   +1 more source

Glucocorticoid exposure and initiation of SSRIs among patients with rheumatoid arthritis: A nested case–control study in UK primary care

British Journal of Clinical Pharmacology, EarlyView.
Aim The immune system might affect the development of anxiety disorders, though mechanisms remain unclear. This nested case–control study investigates whether use of glucocorticoids, potent immunosuppressants, is associated with SSRI initiation (a proxy for pharmacologically treated mental disorders, predominantly depression and/or anxiety).
Elise J. Heesbeen, Patrick C. Souverein, Eibert R. Heerdink, Elisabeth Y. Bijlsma, Lucianne Groenink   +4 more
wiley   +1 more source

The As and Bs of titi monkey linguistics: why emotional communication is not the enemy. [PDF]

Biol Rev Camb Philos Soc
Berthet M, Mesbahi G, Leroux M.
europepmc   +1 more source

Capacity building in medicines development and regulation in Africa—Overview on recent progress

British Journal of Clinical Pharmacology, EarlyView.
Aims Despite advances in health research and digital innovation, many African countries continue to face substantial resource constraints, fragmented capacity‐building efforts and a shortage of skilled professionals in medicines development and regulatory science.
Tirhani Maluleke, Emile Malan, Michael Reid, Patrick Bouic, Haylene Nell, Goonaseelan Pillai, Catriona Waitt, Bernd Rosenkranz   +7 more
wiley   +1 more source

Labelling, Defining and Classifying the Active Ingredients in Oral Language Interventions for Children With or at Risk of Developmental Language Disorder: A Systematic Review and Qualitative Synthesis. [PDF]

Int J Lang Commun Disord
Frizelle P, Murphy D, Murphy L, Fletcher L, O'Leary N, Kerrisk N, Lyons I, Buckley A, Eadie P, Ebbels S, Ferk-Dornstauder M, Jessenitschnig J, Fricke S, Kelic M, Kunnari S, Leitão S, McKean C, McGregor K, Munro N, Murphy CA, Horne AOV.   +20 more
europepmc   +1 more source