Results 51 to 60 of about 590,014 (218)

MELHORIA DA QUALIDADE DE ENSAIOS DE AVALIAÇÃO DE CULTIVARES DE MILHO ATRAVÉS DE INDICADORES DE FERTILIDADE DO SOLO THE USE OF SOIL FERTILITY DATA TO IMPROVE PRECISION OF MAIZE YIELD TRIALS

Ciência Rural, 2001
O presente trabalho teve como objetivo verificar se o uso dos resultados da análise do solo numa análise da covariância com o rendimento de grão, aumenta a precisão experimental dos ensaios de avaliação de cultivares de milho.
Sandra Feijó, Lindolfo Storck, Alessandro Dal'Col Lúcio, Cláudio Lovato, Thomas Newton Martin   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Relação entre diferença mínima significativa e coeficiente de variação nos ensaios de competição de cultivares Relation among least significant difference and coefficient of variation in the cultivar competition trials

Ciência Rural, 1998
O objetivo deste trabalho foi caracterizar ensaios de competição de cultivares de milho, trigo, soja, feijão, cevada, aveia, triticale e sorgo conduzidos no Estado do Rio Grande do Sul e estimar a relação entre a diferença mínima significativa (DMS) e o ...
Alessandro Dal Col Lúcio, Lindolfo Storck   +1 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Productive variability, border use and plot size in trials with cherry tomato

Ciência Rural, 2018
: Knowing the productive variability within protected environments is crucial for choosing the experimental design to be used in that conditions.
Daniel Santos, Alessandro Dal’Col Lúcio, Sidinei José Lopes, Alberto Cargnelutti Filho, Tiago Olivoto   +4 more
doaj   +1 more source

A platform for experimental precision medicine: The extended BXD mouse family. [PDF]

Cell Syst, 2021
Ashbrook DG, Arends D, Prins P, Mulligan MK, Roy S, Williams EG, Lutz CM, Valenzuela A, Bohl CJ, Ingels JF, McCarty MS, Centeno AG, Hager R, Auwerx J, Lu L, Williams RW.   +15 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Melhoria na eficiência dos experimentos de indicalção de cultivares de milho Enhanced efficicency in experiments for maize cultivar indication

Ciência e Agrotecnologia, 2006
Objetivou-se com este trabalho verificar o comportamento da precisão experimental mediante o uso de métodos de correção de produtividade das parcelas experimentais e suas influências sobre a comparação e indicação de cultivares de milho pelo método de ...
Edilson Romais Schmildt, Willian Krause, Cosme Damião Cruz   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Experimental planning for the evaluation of phenotipic descriptors in banana

Revista Brasileira de Fruticultura, 2018
This work aimed to subsidize experimental planning for the evaluation of phenotypic characters in banana. The experiment consisted of a uniformity trial with Tropical cultivar spaced of 3 m x 2 m, in a useful area with nine rows of 40 plants.
Sérgio Luiz Rodrigues Donato, João Abel da Silva, Bruno Vinícius Castro Guimarães, Sebastião de Oliveira e Silva   +3 more
doaj   +1 more source