Results 91 to 100 of about 10,661,924 (343)

Experimental study of the pharmacokinetics of monoclonal antibodies to α4β1-integrin in guinea pigs

Биопрепараты: Профилактика, диагностика, лечение, 2018
This article presents the data on pharmacodynamics evaluation of monoclonal antibodies to α4β1-integrin in guinea pigs. The effect on total content of peripheral blood leukocytes after a single intraperitoneal injection of three doses of the drug has ...
B. N. Krapivin, O. V. Goncharova, E. L. Morozova   +2 more
doaj  

A lens-coupled scintillation counter in cryogenic environment

, 2011
In this work we present an elegant solution for a scintillation counter to be integrated into a cryogenic system. Its distinguishing feature is the absence of a continuous light guide coupling the scintillation and the photodetector parts, operating at ...
, , , , , , , A Amato, A description of this experimental method in condensed matter research can be found in: A. Schenck, A Stoykov, A. Kerek ., I. Britvich ., J A Konter, J Rodriguez, K Sedlak, M Bartkowiak, R Scheuermann   +16 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Estimation of Uniaxial Compressive Strength and Tensile Strength of Sandstone Based on Point Load

Renmin Zhujiang
In rock mechanics and engineering practice, accurate and rapid evaluation of uniaxial compressive strength and tensile strength of rock is important for engineering design and construction safety. Traditional test methods are time-consuming and laborious,
LIU Yongzhi, FANG Qingyao, ZHANG Kun, YAO Huayan, LIU Wu, LIU Guang   +5 more
doaj  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Project Based-Learning (PjBL) as Pedagogical Framework and Poetry Learning Outcomes Among Indonesian Students: An Experimental Study

Educational Process: International Journal
Background/purpose. This study investigates the efficacy of Project-Based Learning (PjBL) as a pedagogical framework for teaching poetry in Indonesian elementary schools.
Mersty Elisabeth Rindengan , Risal Maykel Merentek   +1 more
doaj   +1 more source

Method for design of two-level system of active shielding of power frequency magnetic field based on a quasi-static model

Electrical engineering & Electromechanics
Aim. Development of method for design a two-level active shielding system for an industrial frequency magnetic field based on a quasi-static model of a magnetic field generated by power line wires and compensating windings of an active shielding system ...
B. I. Kuznetsov, A. S. Kutsenko, T. B. Nikitina, I. V. Bovdui, V. V. Kolomiets, B. B. Kobylianskyi   +5 more
doaj   +1 more source

Experimental Research on 4-Duct Tandem VTOL Aircraft Configurations [PDF]

This paper presents a brief summary of several wind-tunnel investigations conducted at the Langley Research Center of the NASA to study the aerodynamic and stability and control characteristics of several VTOL aircraft configurations powered by four ...
Mc Kinney, M. O., Newsom, W. A.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source