Results 101 to 110 of about 5,472,250 (305)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Perceptual outcomes as reinforcers

, 2003
The paucity of basic behavioral research with humans was highlighted almost 40 years ago (Findley, 1966). A recent search of the basic behavioral research journals by the present authors indicated that this situation remains, with only approximately 15 ...
McEwan, James S.A., Sumpter, Catherine E.   +1 more
core  

Project Based-Learning (PjBL) as Pedagogical Framework and Poetry Learning Outcomes Among Indonesian Students: An Experimental Study

Educational Process: International Journal
Background/purpose. This study investigates the efficacy of Project-Based Learning (PjBL) as a pedagogical framework for teaching poetry in Indonesian elementary schools.
Mersty Elisabeth Rindengan , Risal Maykel Merentek   +1 more
doaj   +1 more source

Method for design of two-level system of active shielding of power frequency magnetic field based on a quasi-static model

Electrical engineering & Electromechanics
Aim. Development of method for design a two-level active shielding system for an industrial frequency magnetic field based on a quasi-static model of a magnetic field generated by power line wires and compensating windings of an active shielding system ...
B. I. Kuznetsov, A. S. Kutsenko, T. B. Nikitina, I. V. Bovdui, V. V. Kolomiets, B. B. Kobylianskyi   +5 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Experimental Mechanics of Solids Materials research proceedings ;, 12.

, 2019
Includes bibliographical references and indexes.1 online resource (177 p.)
Pyrzanowski Pawel., Papis Mateusz.
core  

Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse

, 2009
Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control ...
Ulrich Dirnagl, Members of the MCAO-SOP Group   +1 more
core   +2 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

How important are brain banks for alcohol research?

, 2003
This article contains the proceedings of a symposium at the 2002 RSA/ISBRA Meeting in San Francisco, organized and chaired by Clive Harper and co-chaired by Izuru Matsumoto.
Dodd, Peter, Matsumoto, Izuru, Garrick, T, Lewohl, J, Adalsteinsson, Elfar, Butterworth, R, Garrick, Therese, Harper, Clive, Harper, C, Dodd, P, Lewohl, Joanne, Adalsteinsson, E, Sullivan, Edith, Pfefferbaum, A, Butterworth, Roger, Matsumoto, I, Sullivan, E, Pfefferbaum, Adolf   +17 more
core   +1 more source