Results 131 to 140 of about 10,498,087 (284)

ELECTRODE TOOL WEAR AT ELECTRICAL DISCHARGE MACHINING OF SMALL DIAMETER EXTERNAL CYLINDRICAL SURFACES

open access: yesNonconventional Technologies Review, 2015
In a world where minimizing tendency is everywhere, the necessity of obtaining surfaces of small dimensions, but with similar properties and reliability as those with regular dimensions is evident.
Stefan Stoica   +4 more
doaj  

IMPROVING STUDENTS LISTENING COMPREHENSION AT SMKN 1 TANAH GROGOT EAST KALIMANTAN USING DICTOGLOSS STRATEGY [PDF]

open access: yes
The research aims to determine whether the dictogloss strategy improves listening comprehension at SMKN 1 Tanah Grogot or not. The design of this research is quasi-experimental. The population of this research was the students of SMK N 1 Tanah Grogot and
Hasanna, Salsabilla Kirananda
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

NEWS AND INSIGHTS INTO DIMENSIONAL PROCESSING THROUGH ELECTRICAL DISCHARGE MACHINING

open access: yesNonconventional Technologies Review, 2015
The scientific paper presents an experimental research focused in final on the obtained experimental data processing. We can talk about modeling and subsequent about the optimization of the process parameters considering the actual situation.
Mihail Aurel Titu
doaj  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Interdependence investigation of dynamic between the von Willebrand factor and erythrocyte and leukocyte intoxication indices in experimental peritonitis

open access: yesJournal of Education, Health and Sport, 2019
The research was conducted on 175 white rats of reproductive age (3 months), weight of animals - 180-220 g. Animals were divided into 4 groups: Group 1 - 20 intact animals. Group 2 - 50 rats with simulated fecal peritonitis.
I. V. Savytskyi   +6 more
doaj  

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

An Experimental Contribution to the Revision of the Guidelines on Research and Development Agreements [PDF]

open access: yes
The European Commission is working on a revision of its Guidelines on Research and Development Agreements. On this occasion, this note surveys the existing experimental evidence.
Christoph Engel
core  

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