Results 131 to 140 of about 85,673,309 (349)
Empower, innovate, transform: driving the future of health research. 10th anniversary of the Irish Health Research Forum. Recommendations and Event Report [PDF]
This landmark event for the Irish Health Research Forum offered an opportunity to reflect on the key issues addressed by past Forum events and, in particular, to identify the recurring themes that have emerged from the recommendations generated from ...
Health Research Charities Ireland
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Zhileng xuebaoThe electronic expansion valve (EEV) used in multisplit heat pump air conditioners has the structural characteristics of import and export tubes perpendicular to each other, such that the refrigerant has two forms of flow into the EEV, that is, in the ...
Zhu Tianjie +6 more
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2014 This paper presents the first results of empirical-experimental research into the Acquisition of Translation Competence (ATC): the acquisition of declarative knowledge about translation.
PACTE Research Group
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
The damping system for floating caisson of С-1 navigation pass of St.-Petersburg flood protection barrier [PDF]
Инженерно-строительный журнал, 2012 Floating caisson of navigation pass C-1 is designed for shutdown in case of threat of flooding the main ship canal in St.-Petersburg flood protection barrier.
A.S. Bolshev +3 more
doaj
, 1995 This article is the results of a Task Force of the Working group on cardiac arrhythmias of the European society of cardiology (ESC). The consensus document focuses on the fondamentals of experimental models to study cardiac arrhythmogensis and suggest a ...
Study group on experimental research of the working group on arrhythmias of the european society of cardiology +1 more
core
Leveraging experimental designs in tourism economics research
Experimental research represents a significant yet underutilized methodological approach in tourism economics, offering robust tools designed to uncover causal relationships and isolate independent variable effects. Traditional approaches tend to rely on
Souza-Neto, Valerio +3 more
core +1 more source