Results 261 to 270 of about 42,438,687 (307)

Experimental Research on the Possibility of Changing the Adhesion of Epoxy Glue to Concrete. [PDF]

Materials (Basel)
Szewczak A, Łagód G.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

A multifaceted investigation into the impact of m6A methylation-related genes on pancreatic cancer, integrating insights from various databases and foundational experimental research. [PDF]

Ann Med Surg (Lond)
Wen Y, Liu Z, Chen Y.
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Comparative Study of Injected Alzheimer's Disease Models in Rats: Insights from Experimental Research. [PDF]

Pathophysiology
Doumar H, El Mostafi H, Elhessni A, Laaziz A, Mesfioui A.   +4 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Cognitive Activity of an Individual Under Conditions of Information Influence of Different Modalities: Model and Experimental Research. [PDF]

Entropy (Basel)
Petukhov AY, Morozov NS, Krasnitskiy NV, Petukhov YV.   +3 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Experimental Research on Gradation Range and Performance of SMAC13. [PDF]

Materials (Basel)
Zhen Q, Cao W, Dong R, Liu S, Liu N, Zhan Z, Li Y.   +6 more
europepmc   +1 more source

Editorial: The current state of knowledge on asthma-COPD overlap (ACO) in clinical and experimental research: what do we know so far? [PDF]

Front Immunol
Degobbi Tenorio Quirino Dos Santos Lopes F, Tibério IFLC, Fraga Righetti R.   +2 more
europepmc   +1 more source