Results 71 to 80 of about 58,403,547 (305)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Embedding research in the Irish health service. Irish Health Research Forum recommendations and event report. [PDF]
, 2022 This report presents the proceedings of the Irish Health Research Forum event on May 11th 2022, focusing on embedding research in the Irish health service, examining the diversity, opportunities and supporting needs for research in the Irish health ...
Health Research Charities Ireland
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Recommendations on intellectual property and knowledge transfer for charity-funded research [PDF]
, 2018 A core belief of the HRCI is that charity-funded research should be used for public good; for the benefit of patients and to improve the nation’s health.
Medical Research Charities Group
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
BuildingsIn order to investigate the lateral working performance of large-scale steel casing-reinforced concrete pile composite members, this paper sets up large-scale steel casing-reinforced concrete pile composite members with different slenderness ratios λ ...
Duoyin Wang +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
THE JOSEF REGIONAL UNDERGROUND RESEARCH CENTRE (JOSEF URC)
Rudarsko-geološko-naftni Zbornik, 2012 The Josef Gallery, located in the central Bohemia region of the Czech Republic was first excavated in 1981 as an exploration complex for the potential mining of gold.
Dana Pacovská +2 more
doaj
Research on transfering the dynamic process by the spring
Mokslas: Lietuvos Ateitis, 2010 The article describes the particulars of transferring the dynamic process applying the spring and explains the possibilities of diagnostics for support bearings insulated from the external body using resilient elements.
Vytautas Bučinskas, Jevgenij Dmitrijev
doaj +1 more source