Results 81 to 90 of about 42,438,687 (307)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Data protection and the health research regulations: finding a way forward: report and recommendations [PDF]

open access: yes, 2019
This report presents the proceedings of the Irish Health Research Forum meeting on May 16th 2019 which focused on data protection and health research legislation, in the context of the Health Research ...
Medical Research Charities Group
core  

Analytical and Experimental Study of Key Performance of Helicopter Rotor Torsion–Tension Straps

open access: yesActuators
As a crucial component of rotor systems, tension and torsion (TT) straps, recognized for their compact structure, have been adopted in advanced helicopters such as the SB > 1, EC145, and Mi-26.
Yamin Wang, Ruchuan Zhou, Wenjun Huang
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Analysis and Experimental Research on Splice Strength of Aramid Rubber Conveyor Belt

open access: yesMachines
Aramid fiber is increasingly regarded as an important skeleton material in the conveyor belt industry. However, its application is limited by problems such as short splice service life and low strength retention. This study investigates the finger splice
Xiaoxia Zhao   +4 more
doaj   +1 more source

Experimental Data Processing. Part 2 [PDF]

open access: yesPro Ligno, 2011
This paper represents the second part of a study regarding the processing of experimental monofactorialdata, and it presents the original program developed by the author for processing experimental data.Using consecrated methods and relations, this ...
Wilhelm LAURENZI
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Experimental Research on Refrigeration Performance of Quick Freezer

open access: yesZhileng xuebao, 2016
The experiment of quick freezer’s refrigeration system is carried out to study it’s cooling curve and refrigeration performance. The experimental results show that: when the refrigeration system of the quick freezer begins to cool down, the evaporation ...
Chen Xiaoyi, Liu Jinping, Xu Xiongwen
doaj  

Income, education, and policy priorities

open access: yesPolitical Science Research and Methods
Are people's priorities associated with their income and education levels? There is a long history in political science of claims that priorities are driven by economic interests, but also that low-income and low-education people fail to prioritize their
Chris Tausanovitch, Derek E. Holliday
doaj   +1 more source

Novel study designs to investigate the placebo response

open access: yesBMC Medical Research Methodology, 2011
Background Investigating the size and mechanisms of the placebo response in clinical trials have relied on experimental procedures that simulate the double-blind randomized placebo-controlled design.
Klosterhalfen Sibylle   +2 more
doaj   +1 more source

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