Results 221 to 230 of about 10,661,924 (343)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

EXPERIMENTAL RESEARCH FOR EFFECTS OF SKIN IRRITATION ON ORGANISM FUNCTIONING TO MAKE IMMUNBODIES AND ITS REVEALINGS MECHANISM

, 1950
Ataru ADACHI
openalex   +2 more sources

Experimental research on the feasibility of phosphogypsum-enzyme induced carbonate precipitation (EICP) solidified loess. [PDF]

Sci Rep
Dang T, Ji Y, Guo Y, Ma F, Zhang Z, Liang B, Rong X.   +6 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The effects of a YouTube prenatal program on social support, environmental health behavior, and content satisfaction: a quasi-experimental research design. [PDF]

BMC Pregnancy Childbirth
Jeong GH, Kim HK, Min HY.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Numerical and experimental research of amplified spontaneous emission in a high power Nd:YAG slab gain module

, 2019
Yue Shi, Liu Xu, Yi Yu, Lixin Tong, Qingsong Gao, Shiwen Luo   +5 more
openalex   +1 more source

Simulation Prediction and Experimental Research on Surface Morphology of Ball Head Milling Processing. [PDF]

Materials (Basel)
Cui Y, Li X, Zheng M, Mu H, Liu C, Wang D, Yan B, Li Q, Jiang H, Wang F, Hu Q.   +10 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Thermography as a validation technique for experimental-numerical research on fretting fatigue [PDF]

, 2013
De Baets, Patrick, De Pauw, Jan, De Waele, Wim   +2 more
core   +1 more source