Results 131 to 140 of about 79,556,215 (306)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

El documental [PDF]

open access: yes, 1946
Cine experimental (1946). El documental. Cine experimental. (10):147-147.
Cine experimental
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Noticiario [PDF]

open access: yes, 1944
Cine experimental (1944). Noticiario. Cine experimental. (1):63-64.
Cine experimental
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Algunos films significativos de la etapa muda [PDF]

open access: yes, 1945
Cine experimental (1945). Algunos films significativos de la etapa muda. Cine experimental. (5):282-288.
Cine experimental
core  

Experimental Study on the Effects of Refrigerant Inlet and Outlet Flow Directions on the Throttling Noise of Electronic Expansion Valve in Multisplit Heat Pump Air Conditioners

open access: yesZhileng xuebao
The electronic expansion valve (EEV) used in multisplit heat pump air conditioners has the structural characteristics of import and export tubes perpendicular to each other, such that the refrigerant has two forms of flow into the EEV, that is, in the ...
Zhu Tianjie   +6 more
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

El tema [PDF]

open access: yes, 1946
Cine experimental (1946). El tema. Cine experimental. (9):97-97.
Cine experimental
core  

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