Results 111 to 120 of about 8,765,873 (299)

Experimental studies on thermodynamic effects of developed cavitation [PDF]

A method for predicting thermodynamic effects of cavitation (changes in cavity pressure relative to stream vapor pressure) is presented. The prediction method accounts for changes in liquid, liquid temperature, flow velocity, and body scale.
Ruggeri, R. S.
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Clinical trial methods for family medicine and primary care

African Journal of Primary Health Care & Family Medicine
This article outlines the essential features of clinical trials for doctoral or early career researchers. The World Health Organization has recently emphasised the need for higher quality clinical trials, more trials from low- and middle-income countries,
Robert Mash, Bolatito B. Fatusin, Edith Madela-Mntla, Christopher Butler   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Fracture of Wedge-Shaped Body Under Compression

Structural Mechanics of Engineering Constructions and Buildings
The aim is to study the fracture process of a wedge-shaped body during compression. A large number of researchers have turned to the classical solution of the elasticity theory problem of the loaded wedge-shaped body, but the problem of a supported wedge
Leonid Yu. Stupishin, Konstantin E. Nikitin, Alexander V. Masalov   +2 more
doaj   +1 more source

Energy dissipation and equivalent damping of RC columns subjected to biaxial bending: an investigation based in experimental results [PDF]

, 2012
The cyclic behaviour of reinforced concrete columns have been object of many experimental studies in the recent past years. However, the experimental studies on the biaxial response of RC columns are still limited.
Arêde, A., Costa, A. G., Rodrigues, H., Varum, H.   +3 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Experimental parametric studies of transonic T-tail flutter [PDF]

Wind-tunnel tests of the T-tail of a wide-body jet airplane were made at Mach numbers up to 1.02. The model consisted of a 1/13-size scaled version of the T-tail, fuselage, and inboard wing of the airplane.
Ruhlin, C. L., Sandford, M. C.
core   +1 more source