Results 161 to 170 of about 8,711,360 (296)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

The Perception of Names in Experimental Studies on Ethnic Origin: A Cross-National Validation in Europe. [PDF]

Sci Data
Ghekiere A, Martiniello B, Capistrano D, Kuhnle J, Sprong S, Atay P, Boado HC, Creighton M, Di Stasio V, Fernández-Reino M, Hildebrandt J, Kapanadze K, Lachkovska V, Lancee B, Bueno IL, Montag J, Simonovits B, Steinmetz S, Strömberg E, Suárez-Vergne Á, van Oosten S, Vass-Vigh V, Veit S, Zschirnt E, Verhaeghe PP.   +24 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Causal links between serotonin dynamics and cued fear learning: evidence from experimental studies. [PDF]

Front Comput Neurosci
Badripour A, Kim T.
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Qualitative Comparison of LED and LASER Effects on Cutaneous Wound Healing: A Systematic Review of Experimental Studies. [PDF]

Cell Biochem Funct
Miranda MB, Barros ACS, Rocha RBD, Magalhães AT, Cardoso VS.   +4 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

A Comprehensive Review of Computational and Experimental Studies on Skin Mechanics and Meshing: Discrepancies, Challenges, and Optimization Strategies. [PDF]

Biomimetics (Basel)
Razaghi Pey Ghaleh M, Marques D, O'Mahoney D.   +2 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Efficient foam-based thermal interface material functionalized with MWCNTs for CPU cooling applications: thermal performance modeling and Experimental studies. [PDF]

Sci Rep
Ali N, Anis B, Elhadary M.
europepmc   +1 more source