Results 131 to 140 of about 11,296,860 (303)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
STUDIES ON EXPERIMENTAL PORPHYRIA
Nihon Naika Gakkai Zasshi, 1964 Porphyriaの病態は来だ解明されたとは言い難く,動物実験の成績も充分とは云い難い.著者はhexachlorobenzeneを家兎に経口投与することにより,ヒトの急性間欠性porphyriaに類似した臨床症状および尿所見を起こし得た,この実験家兎において尿中porphyrin体,プリン体,クレアチンおよび既成クレアチニンの変動,血清transaminase, cholinesterase活性,肝および赤血球のcatalase活性の変化を経過に従い測定した.又経過中に観察された筋萎縮および全身痙攣の本態を解明するため,筋電図検索を行ない, myogenicおよびneurogenic atrophyを示唆する所見を得た.筋生検の結果,電顕的にも光顕的に屯筋萎縮を示す所見を得た ...
openaire +3 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Ecological IndicatorsSeamounts are geographically isolated, substrate-rich and highly heterogenetic habitats, where little is known about the population shifts and assembly mechanism of the local microbial communities. In this study, microbes in the sediments across a series
Yue Zhang, Hongmei Jing
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
An Experimental Study of Storable Votes [PDF]
The storable votes mechanism is a method of voting for committees that meet periodically to consider a series of binary decisions. Each member is allocated a fixed budget of votes to be cast as desired over the multiple decisions.
Alessandra Casella +2 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source