Results 241 to 250 of about 11,296,860 (303)

A bioinformatics and experimental study toward new therapeutic strategies: CXCL8 in gout progression. [PDF]

Medicine (Baltimore)
Zhang C, Liu C, Yang X, Lin X, Wang M, Yang Y.   +5 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Experimental study on grouting diffusion mechanism of fractured rock. [PDF]

Sci Rep
Zhang C, Li D, Zhang X, Cong Y, Huang Y, Zhang H, Huang Y, Liu Q, Gao X.   +8 more
europepmc   +1 more source

Path Analysis Results on Bone Markers That Influence Accelerated Bone Remodeling: An Experimental Study. [PDF]

Clin Exp Dent Res
Dewi RK, Oktawati S, Gani A, Suhartono E, Hamrun N, Samad R, Natsir N, Apriasari ML, Hasanuddin H.   +8 more
europepmc   +1 more source

Mindfulness-based controlled breathing and the effect on performing a transnasal endoscopy: a quasi-experimental study. [PDF]

Front Med (Lausanne)
Sun L, Sun X, Zhang Z, Zhang X.
europepmc   +1 more source

Effect of Incentive Spirometry Exercise on Perceived Stress in Chronic Obstructive Pulmonary Disease Patients: A Quasi-Experimental Study. [PDF]

Health Sci Rep
Rajpoot NN, Sadiq N, La QD, Sadiq T, Teng E, La HB, Lo DM.   +6 more
europepmc   +1 more source

Pain assessment and management in the emergency department: A prospective quasi-experimental study. [PDF]

J Family Med Prim Care
Pal D, Yadav S, Mishra PR, Kumar A, Das AK, Patra GP, Sahoo AK, Mehul K.   +7 more
europepmc   +1 more source