Results 71 to 80 of about 4,186,728 (268)

Carbon-silicon species are unlikely in subduction-zone fluids

Communications Earth & Environment
In subduction zones, carbon-bearing fluids play a pivotal role in deep carbon cycling and global climate change. Given that Earth’s interior is dominated by silicates, the existence of aqueous carbon-silicon (C-Si) species is crucial for assessing the ...
Nanfei Cheng, I-Ming Chou, Ying Chen, Zhenhao Duan, Xiaolin Wang, Hao Yan   +5 more
doaj   +1 more source

Experimental Studies on Reticulosarcoma [PDF]

Blood, 1951
Abstract 1. Five human lymphatic and myeloid reticulosarcomas were transmitted to fowls in series. 2. The pathologic changes produced in fowls consisted in proliferation of reticulo-endothelial cells (reticulosarcoma and allied conditions) or those of immature myeloid cells (myelosarcoma, myelosis or myeloid metaplasia ...
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Morphofunctional changes of the pelvic organs under conditions of stress urinary incontinence and experimental vaginal prolapse

Репродуктивная эндокринология, 2019
Objective of the study was to analyze the particulars of morphofunctional changes in pelvic organs under conditions of stress urinary incontinence and experimental vaginal prolapse. Materials and methods.
T. F. Tatarchuk, O. О. Yefimenko, V. S. Shkolnikov   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Anxiety and ritualization: Can attention discriminate compulsion from routine?

Communicative & Integrative Biology, 2016
Despite the wide occurrence of ritual behavior in humans and animals, much of its causal underpinnings, as well as evolutionary functions, remain unknown. A prominent line of research focuses on ritualization as a response to anxiogenic stimuli.
Jan Krátký, Martin Lang, John H. Shaver, Danijela Jerotijević, Dimitris Xygalatas   +4 more
doaj   +1 more source

Efficiency Improvement of Switched Reluctance Generator Using Optimization Techniques

Transactions on Environment and Electrical Engineering, 2017
This article introduces the switched reluctance machine operating as a generator. This kind of electrical machine delivers CC power at the output and the energy generated can be controlled through several variables.
Márcio Rodrigues da Cunha Reis, Wanderson Rainer Hilário de Araújo, Wesley Pacheco Calixto   +2 more
doaj   +1 more source