Results 151 to 160 of about 12,685,705 (296)

Elucidating the Mechanism of Oridonin in Treating Hepatocellular Carcinoma: Network Pharmacology and Experimental Validation. [PDF]

J Cell Mol Med
Li L, Guo X, Wang G, Zhang J, Wang J, Miao S, Sun Y, Ma S, Shi X.   +8 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Identification and experimental validation of aging-related biomarkers in intervertebral disc degeneration. [PDF]

Sci Rep
Zhang F, Yuan L, Ding H, Lou Z, Li X.
europepmc   +1 more source

Computational Repurposing and Experimental Validation of YBX1 Inhibitors in Hepatocellular Carcinoma. [PDF]

Biomedicines
Karkoutly O, Nagati V, Chauhan SC, Tripathi M.   +3 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Coarse-Grained Modeling and Interpretation of Phenomenological Creep Rate Behavior with Experimental Validation. [PDF]

Entropy (Basel)
Gong T, Zhou D, Guan X, Du YM.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Computational Modeling and Experimental Validation of Variabilities in Chemical Vapor Deposition of Graphene on Metals. [PDF]

Small
Joshi T, Raman RKS, Ventikos Y.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Integrative Analysis and Experimental Validation Identify Potential m6A-Related Biomarkers for Osteoporosis. [PDF]

Genes (Basel)
Wang Z, Chen Y, Yang Y, Xu B, Jiao X, Qi L.   +5 more
europepmc   +1 more source