Results 121 to 130 of about 11,190,422 (282)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Competency Learning by Machine Learning-Based Data Analysis with Electroencephalography Signals
Education SciencesData analysis and machine learning have become essential cross-disciplinary skills for engineering students and professionals. Traditionally, these topics are taught through lectures or online courses using pre-existing datasets, which limits the ...
Javier M. Antelis +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Between syntax and morphology: German noun+verb units
GlossaWe show that graphemic variation—at least in some writing systems—can be analysed in terms of grammatical variation given a usage- based probabilistic view of the grammar-graphemics interface.
Roland Schäfer, Ulrike Sayatz
doaj +2 more sources
Experiments with Gorenstein Liaison
, 2001 We give some experimental data of Gorenstein liaison, working with points in ${\mathbb P}^3$ and curves in ${\mathbb P}^4$, to see how far the familiar situation of liaison, biliaison, and Rao modules of curves in ${\mathbb P}^3$ will extend to ...
Hartshorne, Robin
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Experimental analysis of physical properties of lightweight gypsum plasterboard
Acta Polytechnica CTU ProceedingsThis article presents an experimental analysis of a newly developed gypsum plasterboard for dry construction. The new board has a density that is 40 kgm−3 lower than existing boards and was created with an emphasis on conserving resources and reducing ...
Martin Hataj +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source