Seismicity diagnostic of permeability creation from centimeter to subkilometer scales in crystalline rock during shear stimulation. [PDF]
Yu P +4 more
europepmc +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
In Vitro Metabolism and Analytical Characterization of SLU-PP-332 and SLU-PP-915: Novel Pan-ERR Agonists With Doping Potential. [PDF]
Möller T, Krug O, Thevis M.
europepmc +1 more source
LEP Experiments Committee: Minutes of the 44th meeting on 19 November 1996 [PDF]
CERN. Geneva. LEP Experiments Committee
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
A Critical Evaluation of the Limiting Current Density in Polymer Electrolytes: Interplay of Ion Transport, Mechanical Stability, and Conformal Li-Electrolyte Interfaces. [PDF]
Röring P +8 more
europepmc +1 more source
Minutes of the 56th meeting, 3 November 2000 [PDF]
CERN. Geneva. LEP Experiments Committee
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Dynamic activity of Erg promotes maturation of the hematopoietic system. [PDF]
Tanaka-Yano M +14 more
europepmc +1 more source

