Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez +6 more
wiley +1 more source
A novel patient-Centered approach to clinical trial readiness in rare diseases: Application in Aicardi-Goutières Syndrome (AGS). [PDF]
Sevagamoorthy A +29 more
europepmc +1 more source
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni +7 more
wiley +1 more source
Algorithms on Trial: Does evaluative probabilistic reporting of forensic evidence infringe the presumption of innocence? [PDF]
Sallavaci O.
europepmc +1 more source
Matrix Stiffness Directs Stemness Signatures in Breast Cancer
We built lab‐grown breast cancer models to study how the stiffness of the tumor's surroundings influences cancer behavior. Softer environments encouraged more stem‐like, drug‐resistant cells, while stiffer ones kept cells more differentiated. These findings show that tissue mechanics drive cancer diversity and drug resistance, offering new insights for
Chantal Kopecky +4 more
wiley +1 more source
The impact of hospital pharmacists' psychological contracts on medication adherence management: The mediating role of job burnout. [PDF]
Luo Y +8 more
europepmc +1 more source
AI‐Assisted Workflow for (Scanning) Transmission Electron Microscopy: From Data Analysis Automation to Materials Knowledge Unveiling. Abstract (Scanning) transmission electron microscopy ((S)TEM) has significantly advanced materials science but faces challenges in correlating precise atomic structure information with the functional properties of ...
Marc Botifoll +19 more
wiley +1 more source
Assessing the impact of a social cognitive theory-based educational intervention on ergonomic behaviors: a randomized controlled trial utilizing a learning-by-doing approach. [PDF]
Hosseini ZS +3 more
europepmc +1 more source
Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi +4 more
wiley +1 more source
A Bayesian network approach to evaluating footwear evidence. [PDF]
Kellett D +3 more
europepmc +1 more source

