Results 151 to 160 of about 1,398,079 (317)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
The modifiability of rule-based expert systems
, 1985 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis examines the claim that rule representations of knowledge are conveniently modified. The thesis falls into two parts and in the first, a precise
Bottaci, Leonardo
core
Proposal skripsi adalah rencana penelitian yang diajukan oleh mahasiswa dengan bimbingan dari Dosen Pembimbing, dan disusun mengikuti aturan penulisan karya ilmiah.
E, Erlangga; Universitas Bandar Lampung +2 more
core +1 more source
Common long-term complications of adult congenital heart disease: avoid falling in a H.E.A.P.
, 2015 Advances in cardiology and cardiac surgery have transformed the outlook for patients with congenital heart disease (CHD) so that currently 85% of neonates with CHD survive into adult life.
Alonso-Gonzalez, R +3 more
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Implicit learning of expert chess knowledge
, 2003 This article discusses how CHREST's mechanisms lead to the implicit learning of a large number of chunks, which underpin (expert) behaviour in a number of domains.
Gobet, F
core
Klasifikasi data pada studi kasus data penerima bantuan sosial berfungsi untuk mengklasifikasi berdasarkan label atau kelas yang menjadi indikasi rekomendasi penerima bantuan social.
Kurniawan, Ahmad Shaleh; Universitas Bandar Lampung +2 more
core +1 more source