Results 131 to 140 of about 455,097 (266)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Evaluation of large language model responses to patient questions on oral anticoagulant therapy: a comparative expert assessment. [PDF]

Explor Res Clin Soc Pharm
Khan MA, Chaudhary V, Maazuddin M, Sultan I, Mehnaaz S, Pal B.   +5 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Real-world agreement in the ultrasound classification of subcapsular thyroid nodules: comparison with expert assessment. [PDF]

Thyroid Res
Trimboli P, Papini E, Novizio R, Deandrea M, Frasoldati A, Durante C, Leoncini A, Guglielmi R.   +7 more
europepmc   +1 more source

Risk models for VTE and bleeding in medical inpatients: systematic identification and expert assessment. [PDF]

Blood Adv, 2020
Darzi AJ, Karam SG, Spencer FA, Spyropoulos AC, Mbuagbaw L, Woller SC, Zakai NA, Streiff MB, Gould MK, Cushman M, Charide R, Etxeandia-Ikobaltzeta I, Germini F, Rigoni M, Agarwal A, Morsi RZ, Akl EA, Iorio A, Schünemann HJ.   +18 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Evaluation of ChatGPT-5-generated clinical management recommendations for HPV infection and cervical premalignant lesions: a scenario-based expert assessment study. [PDF]

BMC Med Inform Decis Mak
Gokkaya M, Yalcin N, Alci A, Taşkum İ.
europepmc   +1 more source

Investigational plasma kallikrein inhibitors for the treatment of diabetic macular edema: an expert assessment. [PDF]

Expert Opin Investig Drugs, 2020
Bhatwadekar AD, Kansara VS, Ciulla TA.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Portable perimetry devices for glaucoma patients -practicality in daily clinical practice and glaucoma expert assessment. [PDF]

Graefes Arch Clin Exp Ophthalmol
Schrittenlocher S, Lüke V, Irle H, Weliwitage J, Lüke JN, Enders P, Hoffmann E, Rosentreter A, Lübke J, Dinslage S, Widder RA, Kong G, Vingrys AJ, Cursiefen C, Dietlein TS, Lappas A.   +15 more
europepmc   +1 more source