Results 81 to 90 of about 1,576,511 (290)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Variability of expert assessments of ECG time domain parameters. [PDF]
Eur J Anaesthesiol Intensive Care, 2023 Böck C +4 more
europepmc +1 more source
Assessments of the Expert Evidence of Accountants
Australian Accounting Review, 2004 The capacity of expert accounting witnesses to provide understandable evidence has been challenged by Australian judges. They have assessed expert accounting evidence as the most difficult evidence, from eight disciplinary areas, for them to evaluate adequately.
Craig, Russell, Reddy, Prasuna
openaire +2 more sources
The Future Prospect of PV and CSP Solar Technologies: An Expert Elicitation Survey [PDF]
In this paper we present and discuss the results of an expert elicitation survey on solar technologies. Sixteen leading European experts from the academic world, the private sector and international institutions took part in this expert elicitation ...
Giulia Fiorese +3 more
core
Risk Analysis for Autonomous Underwater Vehicle Operations in Extreme Environments [PDF]
, 2010 Autonomous underwater vehicles (AUVs) are used increasingly to explore hazardous marine environments. Risk assessment for such complex systems is based on subjective judgment and expert knowledge as much as on hard statistics.
Brito, M. +5 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
[The problem of long/post-COVID in expert assessments]. [PDF]
Unfallchirurgie (Heidelb), 2023 Eyfferth T +8 more
europepmc +1 more source
Bayesian and Consistent Assessments [PDF]
In a Bayesian assessment beliefs are computed from the strategy profile following Bayes’ rule at positive probability information sets and for every subgame.
Carlos Pimienta
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source