Results 81 to 90 of about 7,016,907 (343)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Framing a Knowledge Base for a Legal Expert System Dealing with Indeterminate Concepts

The Scientific World Journal, 2015
Despite decades of development of formal tools for modelling legal knowledge and reasoning, the creation of a fully fledged legal decision support system remains challenging.
Michał Araszkiewicz, Agata Łopatkiewicz, Adam Zienkiewicz, Tomasz Zurek   +3 more
doaj   +1 more source

Extending the Foundational Model of Anatomy with Automatically Acquired Spatial Relations [PDF]

, 2009
Formal ontologies have made significant impact in bioscience over the last ten years. Among them, the Foundational Model of Anatomy Ontology (FMA) is the most comprehensive model for the spatio-structural representation of human anatomy.
Christian Folz, Manuel Mö, Michael Sintek, Pinar Wennerberg, Sascha Seifert   +4 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An hierarchical approach to performance evaluation of expert systems [PDF]

The number and size of expert systems is growing rapidly. Formal evaluation of these systems - which is not performed for many systems - increases the acceptability by the user community and hence their success.
Dominick, Wayne D., Kavi, Srinu
core   +1 more source

Transforming concepts in patient safety: a progress report

BMJ Quality & Safety, 2018
In 2009, the National Patient Safety Foundation’s Lucian Leape Institute (LLI) published a paper identifying five areas of healthcare that require system-level attention and action to advance patient safety.The authors argued that to truly transform the ...
T. Gandhi, G. Kaplan, L. Leape, D. Berwick, S. Edgman-Levitan, A. Edmondson, G. Meyer, D. Michaels, J. Morath, C. Vincent, R. Wachter   +10 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Knowledge Author: Facilitating user-driven, Domain content development to support clinical information extraction [PDF]

, 2016
Background: Clinical Natural Language Processing (NLP) systems require a semantic schema comprised of domain-specific concepts, their lexical variants, and associated modifiers to accurately extract information from clinical texts.
Chapman, WW, Drews, FA, Liu, Y, Mowery, D, Scuba, W, Tharp, M, Tseytlin, E   +6 more
core   +4 more sources

Key topics for quantum mechanics at secondary schools: a Delphi study into expert opinions

International Journal of Science Education, 2018
This article describes a Delphi study aiming to investigate which quantum mechanics topics experts consider to be important to teach at the secondary level, and what arguments these experts give.
K. Krijtenburg-Lewerissa, H. Pol, A. Brinkman, W. R. Joolingen   +3 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source