Results 301 to 310 of about 2,735,740 (399)

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

A core curriculum for pediatric lung ultrasound: an expert consensus. [PDF]

Ital J Pediatr
Musolino AM, Di Sarno L, Buonsenso D, Tomà P, Natali GL, Bock C, Mesturino MA, Scateni S, Corsello A, Chiaretti A, Villani A, Agostiniani R.   +11 more
europepmc   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Expert consensus on the off-label use of drugs for pediatric rare diseases in China (2025 edition). [PDF]

Transl Pediatr
Mo X, Deng H, Yang J, Li J, Ouyang S, Chen F, Cui Y, Gao X, Jiang H, Li X, Liu L, Liu J, Qiu L, Rong X, Wen Z, Wang J, Zeng P, Zhang W, Zhao X, Zhou J, Chen J, Chen P, Chen W, Chen Z, Fang R, Fan X, Jia Y, Li Z, Li X, Li X, Lin Y, Liu M, Mai H, Miao J, Wang X, Wang Y, Wang J, Wei L, Wu J, Yu S, Zeng L, Zhang B, Zhang H, Zheng Z, Chen X, Xia S, Zhou W, Sun J, Li Y, Rare Disease Expert Committee of Guangdong Pharmaceutical Association.   +49 more
europepmc   +1 more source

A Natural Sweetener‐inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals

Advanced Science, EarlyView.
This study develops a natural sweetener, the psicose‐inducible transgene expression (PURE) system based on an Agrobacterium tumefaciens–derived transcriptional repressor PsiR. The PURE system is highly specific to psicose, being insensitive to other sugars and structurally similar molecules.
Longliang Qiao, Zhihao Wang, Shasha Tang, Yuan Fang, Guiling Yu, Xiaoting Qiu, Lingxue Niu, Tao Yan, Xingwan Liu, Xiaoding Ma, Deqiang Kong, Yang Zhou, Ningzi Guan, Jinzhong Tian, Meiyan Wang, Haifeng Ye, Fengfeng Cai   +16 more
wiley   +1 more source

Expert consensus on quality control of colposcopy

Gynecology and Obstetrics Clinical Medicine
Linhong Wang, Xiaosong Zhang, Lihui Wei, Gengli Zhao, Hui Bi   +4 more
doaj   +1 more source

Surgeon's aspect of an expert consensus-based practical recommendation for surgical treatment of hepatocellular carcinoma. [PDF]

Ann Surg Treat Res
Cho JY.
europepmc   +1 more source

The Utility of Smart Multiple Daily Injection Systems in Intensive Insulin-Treated People With Diabetes: An Italian Expert Consensus

Francesco Giorgino, Riccardo Bonfanti, Filomena Castaldo, Concetta Irace, Andrea Laurenzi, Claudio Maffeis, Giovanni Pappagallo, Dario Pitocco, Ivana Rabbone, Emanuela Zarra, Andrea Scaramuzza   +10 more
openalex   +1 more source

Highlights of the EORTC St. Gallen International Expert Consensus on the primary therapy of gastric, gastroesophageal and oesophageal cancer – Differential treatment strategies for subtypes of early gastroesophageal cancer

, 2012
Manfred P. Lutz, John Zalcberg, Michel Ducreux, Jaffer A. Ajani, William Allum, Daniela Aust, Yung‐Jue Bang, Stefano Cascinu, Arnulf H. Hölscher, Janusz Jankowski, Edwin P.M. Jansen, Ralf Kisslich, Florian Lordick, C. Mariette, Markus Moehler, Tsuneo Oyama, Arnaud Roth, Josef Rueschoff, Thomas Ruhstaller, Raquel Seruca, M. Stahl, Florian Sterzing, Eric Van Cutsem, Ate van der Gaast, Jan van Lanschot, Marc Ychou, Florian Otto   +26 more
openalex   +2 more sources

Spatio‐Temporal Proteomic Landscape Reveals Early Warning Signals of Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
This study constructs a proteomic atlas of esophageal squamous cell carcinoma (ESCC) progression using esophageal biopsy samples. It identifies moderate dysplasia as the critical turning stage and a seven‐protein panel for early detection. Functionally, GBP6 loss promotes ESCC progression via cell cycle and epithelial‐mesenchymal transition (EMT ...
Xumiao Li, Jie Yuan, Min Gao, Jibin Liu, Qinqin Wang, Yaqi Zhang, Mingtao Cao, Xiaolin Hu, Hui Yang, Jun Li, Chen Li, Xiaoguang Li, Hui Wang   +12 more
wiley   +1 more source