Results 91 to 100 of about 5,111,330 (297)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Using Pretest-Posttest Research Designs to Enhance Jury Decision-Making

open access: yesOñati Socio-Legal Series, 2015
When lay jurors are unfamiliar with key evidentiary issues, expert evidence, judicial instructions and group deliberation may enhance their understanding of this evidence.
Jane Goodman-Delahunty   +2 more
doaj  

The Admissibility of Scientific Expert Evidence Under Indonesian Criminal Justice System

open access: yesSriwijaya Law Review, 2019
In many cases, such as corruption and forestry-related crimes, an expert has a significant role in explaining the impact of the crime. For instance, scientific expert evidence is required to disclose about the ecological destruction that occurred due to ...
Wanodyo Sulistyani
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

A transparent approach: Openness in forensic science reporting

open access: yesForensic Science International: Synergy
There have been numerous calls for increased transparency and disclosure in forensic science. However, there is a paucity of guidance on how to achieve this transparency in reports, and the impacts it may have on criminal justice proceedings. We describe
Kaye N. Ballantyne   +6 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Principal Directions of Evaluation of Expert Evidence

open access: yesVestnik Omskoj Ûridičeskoj Akademii, 2015
The article deals with the evaluation procedure of expert evidence, which was prepared subsequent to the results of the examination of evidence.
Kuznetsov A. A.
doaj  

Expert examination of evidence in criminal proceedings

open access: yesКриміналістика і судова експертиза
The article is dedicated to elucidating the essence of expert examination of evidence as a component of evidentiary activity in criminal proceedings. Expert examination of evidence, as a component of evidentiary activity, is distinguished from judicial ...
Артем Коваленко
doaj   +1 more source

Calculating and understanding the value of any type of match evidence when there are potential testing errors [PDF]

open access: yes, 2014
It is well known that Bayes’ theorem (with likelihood ratios) can be used to calculate the impact of evidence, such as a ‘match’ of some feature of a person. Typically the feature of interest is the DNA profile, but the method applies in principle to any
Hsu, A, Neil, M, Fenton, NE
core   +1 more source

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