Results 81 to 90 of about 5,111,330 (297)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Promise of Evidence-Based Policymaking
, 2017 Report of the Commission on Evidence-Based Policymaking providing a final report of their findings that..
United States. Commission on Evidence-Based Policymaking.
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Re-Thinking Expert Evidence [PDF]
, 2019 The jurisprudence surrounding expert evidence in Canadian law has evolved since the 1994 case, R. v. Mohan, but it is still replete with numerous problems.
Freedman, Joshua A.M.
core +1 more source
Commission on Evidence-Based Policymaking
, 2017 Website for the Commission on Evidence-Based Policymaking (CEP), which was established to create a strategy for increasing access to data about government programs while protecting confidentiality. It includes hearings, meeting minutes, and news as well
United States. Commission on Evidence-Based Policymaking.
core
, 2023 This article argues that Kathleen Folbigg was wrongly convicted of suffocating her four children and should be immediately released from prison where she has been incarcerated since 2003. The basis for this contention is the fresh and compelling evidence
Hum, Fiona, Hemming, Andrew
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The Promise of Evidence-Based Policymaking: Appendices E-H
, 2017 Supplementary appendices that support the final report of the Commission on Evidence-Based Policymaking including ..
United States. Commission on Evidence-Based Policymaking.
core
Consultation document: Bearing good witness - Proposals for reforming the delivery of medical expert evidence in family law cases [PDF]
, 2007 Several high‐profile criminal cases, such as those of Sally Clark, Angela Cannings, Trupti Patel and Donna Anthony – all wrongly convicted of the murder of their children on the basis of flawed expert evidence – have raised serious questions about the ...
Heenan, Susan +2 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source