Results 61 to 70 of about 9,953 (189)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Using Pretest-Posttest Research Designs to Enhance Jury Decision-Making
Oñati Socio-Legal Series, 2015 When lay jurors are unfamiliar with key evidentiary issues, expert evidence, judicial instructions and group deliberation may enhance their understanding of this evidence.
Jane Goodman-Delahunty +2 more
doaj
The Admissibility of Scientific Expert Evidence Under Indonesian Criminal Justice System
Sriwijaya Law Review, 2019 In many cases, such as corruption and forestry-related crimes, an expert has a significant role in explaining the impact of the crime. For instance, scientific expert evidence is required to disclose about the ecological destruction that occurred due to ...
Wanodyo Sulistyani
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A transparent approach: Openness in forensic science reporting
Forensic Science International: SynergyThere have been numerous calls for increased transparency and disclosure in forensic science. However, there is a paucity of guidance on how to achieve this transparency in reports, and the impacts it may have on criminal justice proceedings. We describe
Kaye N. Ballantyne +6 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Principal Directions of Evaluation of Expert Evidence
Vestnik Omskoj Ûridičeskoj Akademii, 2015 The article deals with the evaluation procedure of expert evidence, which was prepared subsequent to the results of the examination of evidence.
Kuznetsov A. A.
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Expert examination of evidence in criminal proceedings
Криміналістика і судова експертизаThe article is dedicated to elucidating the essence of expert examination of evidence as a component of evidentiary activity in criminal proceedings. Expert examination of evidence, as a component of evidentiary activity, is distinguished from judicial ...
Артем Коваленко
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source