Results 131 to 140 of about 5,111,330 (297)

Defining expert opinion in clinical guidelines: insights from 98 scientific societies – a methodological study

open access: yesBMC Medical Research Methodology
Background The use of Expert Opinion (EO) in clinical guidelines is highly variable and lacks standardization, leading to ongoing controversy. A clear and universally accepted definition of EO is also lacking.
Blin Nagavci   +2 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Evidence into recommendations: How expert groups formulate clinical guidelines

open access: yes, 2009
This report outlined the findings of the Evidence into Recommendations study, identifying the key influences on decision making in the formulation of clinical guidelines.
McAteer, J.   +3 more
core  

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Evidence summary: COVID-19 - physiotherapy rehabilitation [v2.0]

open access: yes, 2020
A team of expert researchers and clinicians within the intensive care and acute cardiorespiratory fields have collaborated to produce: Physiotherapy management for COVID-19 in the acute hospital setting: recommendations to guide clinical practice1. These
National Health Library and Knowledge Service Evidence Team
core  

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Criminal profiling as expert evidence

open access: yes, 2014
This chapter looks at profiling as expert evidence. While not allowed in many jurisdictions, others have been more receptive to this type of expert testimony.
Petherick, Wayne   +7 more
core   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Objectification of injuries and consequences in expert medical opinions

open access: yesZdravniški Vestnik, 2007
Background: Only unequivocal evidence confirming the total extent of injury. Biomechanical analysis, objectifications of permanent consequences after injury and objectification, whether such injuries influence life activities of an injured person, should
Miran Vrabl
doaj  

Summary Document: Evidence Sources for Mildly Symptomatic COVID-19 Treated in a Non-Hospital Setting

open access: yes, 2020
The following information resources have been selected by the National Health Library and Knowledge Service Evidence Virtual Team in response to a request to collate the best available evidence and guidance pertaining to asymptomatic or mildly ...
National Health Library and Knowledge Service Evidence Team
core  

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