Results 31 to 40 of about 2,706,996 (304)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Design of an emergency medical information system for mass gatherings

Heliyon
Background: The frequency of mass gatherings is increasing. Such events often involve many people and carry the risk of mass casualty incidents, which require substantial medical resources from various healthcare institutions. The current medical system,
Yu Tian, Zhuyi Shen, Yinghao Zhao, Tianshu Zhou, Qiang Li, Mao Zhang, Jingsong Li   +6 more
doaj   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Expert System for UNIX System Reliability and Availability Enhancement [PDF]

, 1993
Highly reliable and available systems are critical to the airline industry. However, most off-the-shelf computer operating systems and hardware do not have built-in fault tolerant mechanisms, the UNIX workstation is one example.
Xu, Catherine Q.
core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

DEVELOPING AN EXPERT SYSTEM FOR THE SELECTION OF SUITABLE DAM SITES IN YEME

مجلة العلوم الهندسية والتقنية, 2023
Dam construction is considered as one of the main aims of water resources development in Yemen. However, dam construction has many drawbacks such as the lack of considering integrated management in dams’ construction.
Ahmed M. ALGunaid
doaj   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

High-precision crop recommendation system with stacking ensemble classifiers for optimizing agricultural productivity

Scientific Reports
Crop productivity is crucial for farmers and economy worldwide. Factors such as fertilization, weather, and climate have a significant impact on yields. To improve crop productivity, a crop recommendation system is introduced in this paper.
Rania A. Ahmed, Walid El-Shafai, Zeinab A. Ahmed, El-Sayed M. El-Rabaie, Fathi E. Abd El-Samie   +4 more
doaj   +1 more source

Pediatric Oncology Nursing Competencies in Latin America and the Caribbean: A Scoping Review to Inform Practice, Education, and Research

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Nurses are central to cancer care for children and adolescents, yet no comprehensive synthesis has defined essential core competencies for pediatric oncology nursing (PON) practice internationally, particularly in Latin America and the Caribbean (LAC).
Luís Carlos Lopes‐Júnior, Edmara Bazoni Soares Maia, Soad Fuentes‐Alabí, Courtney E. Sullivan, Monnie Abraham, Mauricio Maza, Liliana Vásquez Ponce, Regina Aparecida Garcia Lima   +7 more
wiley   +1 more source

Responsive nanomedicine strategies achieve pancreatic cancer precise theranostics

Bioactive Materials
Pancreatic ductal adenocarcinoma (PDAC), the predominant subtype of pancreatic cancer, ranks among the deadliest malignancies worldwide, with a 5-year survival rate remaining below 13 %.
Fangjian Li, Zixiang Tang, Yating Zheng, Tao Jiang, Lin Deng, Wenjie Dai, Yuxing Zhao, Nan Zheng, Siman Liu, Yuxuan Fan, Sihan Lu, Yanxi Chen, Gang Liu, Yang Zhang, Yongfu Xiong   +14 more
doaj   +1 more source