Results 151 to 160 of about 27,795,417 (374)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

TES: A modular systems approach to expert system development for real-time space applications [PDF]

open access: yes
A major goal of the Space Station era is to reduce reliance on support from ground based experts. The development of software programs using expert systems technology is one means of reaching this goal without requiring crew members to become intimately ...
Cacace, Ralph, England, Brenda
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Applications of expert systems for satellite autonomy [PDF]

open access: yes
Some aspects of the on-board application of expert systems in artificial satellites are discussed. The activities of the study, which include the implementation of two prototypes on a dedicated artificial intelligence machine, are described.
Ciarlo, A., Donzelli, P.
core   +1 more source

Extracting causal relationships from Chinese written text [PDF]

open access: yes, 2002
Expert systems form one of the most important research areas in Artificial Intelligence. The main parts in expert systems are knowledge bases and inference engines.
Hoede, C., Liu, X.
core   +1 more source

Rule-based expert systems

open access: yesRadiopaedia.org, 2017
B. Buchanan   +5 more
semanticscholar   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

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