Results 91 to 100 of about 3,278,711 (345)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Dialogue expertise in man-machine systems [PDF]
, 1989 The present paper considers the nature of interaction in man-machine systems with special attention to the role of dialogue. Based upon this understanding, a concept of 'dialogue expertise' is derived in a specific facility for mediation.
Weir, G.R.S.
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Explicit recognition of emotional facial expressions is shaped by expertise: evidence from professional actors [PDF]
, 2013 Can reading others' emotional states be shaped by expertise? We assessed processing of emotional facial expressions in professional actors trained either to voluntary activate mimicry to reproduce character's emotions (as foreseen by the “Mimic Method”),
Conson, Massimiliano +6 more
core +2 more sources
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Expertise in rural development: A conceptual and empirical analysis
World Development, 2019 Understandings of socially distributed expertise as being key to living, interpreting and intervening in the world, are increasingly used in development narratives, referring usually to knowledge sharing across multi-stakeholder partnerships.
P. Lowe +3 more
semanticscholar +1 more source
Expertise revisited I: Interactional Expertise
, 2016 39 pages, one ...
Collins, Harry, Evans, Robert
openaire +2 more sources
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
BMC Health Services ResearchBackground Acquired brain injury (ABI) can pose significant challenges, particularly during the transition from rehabilitation to independent living. Peer support, provided by individuals with similar experiences, may enhance self-management, emotional ...
M. J. J. Voorn +3 more
doaj +1 more source