Results 91 to 100 of about 2,905,481 (303)
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Financial Expertise of Directors [PDF]
The composition and functioning of corporate boards is at the core of the academic and policy debate on optimal corporate governance. But does board composition matter for corporate decisions?
A. Burak Güner +2 more
core
Expertise with non-speech 'auditory Greebles' recruits speech-sensitive cortical regions [PDF]
, 2009 Regions of the human temporal lobe show greater activation for speech than for other sounds. These differences may reflect intrinsically specialized domain-specific adaptations for processing speech, or they may be driven by the significant expertise we ...
Devlin, JT, Dick, F, Holt, LL, Leech, R
core
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Specialized Trial Courts: Concentrating Expertise on Fact [PDF]
, 2002 In the absence of a specialized patent trial court with expertise in fact-finding, the Court of Appeals for the Federal Circuit often reviews de novo the many factual questions that pervade patent law.
Rai, Arti K.
core +1 more source
What’s So Special About Patent Law? [PDF]
, 2016 The widespread belief that patent law is special has shaped the development of patent law into one of the most specialized areas of the law today. The belief in patent law’s exceptionalism manifests itself as two related presumptions with respect to the ...
Brook, Gary +6 more
core +2 more sources
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
ProceedingsBackground and Objectives: Excessive deposits of white adipose tissue lead to obesity. Preadipocyte differentiation, adipocyte metabolism, and some inflammatory and profibrotic factors are key in modulating early fat mass expansion and chronic low-grade ...
Catherine Lefranc-Millot +4 more
doaj +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Presidential Control, Expertise, and the Deference Dilemma [PDF]
, 2012 Courts reviewing agency action frequently point to superior political accountability and expertise as justifying deference to agencies. These fundamentals of deference often operate in tandem, providing distinct but complimentary reasons why courts will ...
Meazell, Emily Hammond
core +1 more source