Results 41 to 50 of about 646,275 (267)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 2020 We will soon be surrounded by artificial systems capable of cognitive performance rivaling or exceeding a human expert in specific domains of discourse. However, these cogs need not be capable of full general artificial intelligence nor able to function in a stand-alone manner.
Ron Fulbright, Grover Walters
openaire +2 more sources
Pharmacokinetics of enalapril in patients with arterial hypertension depending on the glomerular filtration rate [PDF]
КардиоСоматика, 2019 Aim. To study the pharmacokinetics of enalapril in patients with arterial hypertension, depending on the value of the prescribed dose of enalapril and the state of renal function to improve the efficiency and safety of treatment.
Marina V. Zhuravleva +6 more
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
New Left Review, 2017 ‘Terribly unjust, subject to crisis, environmentally unwise, everywhere politically and economically captured by the few, and yet somehow impossible for anyone to alter or escape’: this is the world David Kennedy presents us with in his new book, A World of Struggle.
openaire +1 more source
Антибиотики и Химиотерапия, 2020 Substances for manufacture of parenteral drugs require control by the «Bacterial Endotoxin» (BE) Index with the LAL-test. The aim of the study was to show possible applicability of organic solvents in BE determination by the gel-thromb test in case of ...
O. V. Shapovalova +3 more
doaj
Проблемы особо опасных инфекций, 2015 Investigated have been cultural-morphological, biochemical and genetic properties of lyophilized cultures of F. tularensis 15 NIIEG vaccine strain, accumulated within 60-years term and deposited at the State Collection of Pathogenic Microorganisms of ...
E. A. Solov’Ev +4 more
doaj +1 more source
BMC Health Services Research, 2022 Background Torture, abuse and dental anxiety (TADA) are often precursors to developing a pathological relationship with dental care due to elevated anxiety. Consequently, patients who suffer from one or more of these tend to avoid dental services.
Emilie Bryne +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Trials, 2020 Background In the Netherlands, midwives are required to use the ‘V-MIS’ (Minimal Intervention Strategy for Midwives) smoking cessation counselling protocol to help pregnant women quit smoking.
Jeroen Bommelé +5 more
doaj +1 more source