Results 161 to 170 of about 3,416,168 (298)

Fact-Checking Large Language Model Responses to a Health Care Prompt: Comparative Study. [PDF]

JMIR Form Res
Ryan P, Davoren O, Elwyn G.
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

UNH Experts Available to Discuss Bullying [PDF]

, 2010
Wright, Lori
core   +2 more sources

Real-world agreement in the ultrasound classification of subcapsular thyroid nodules: comparison with expert assessment. [PDF]

Thyroid Res
Trimboli P, Papini E, Novizio R, Deandrea M, Frasoldati A, Durante C, Leoncini A, Guglielmi R.   +7 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Transforming a team of experts into an expert team [PDF]

Resuscitation, 2016
openaire   +2 more sources

Development, content validation and quality evaluation of a mobile app for oral health surveillance: a modified Delphi approach. [PDF]

J Oral Biol Craniofac Res
Sakthi K, Sankeshwari RM, Ankola AV, Roychowdhury B, Santhosh VN, Dutta D, Varghese AS, Apoorva SR.   +7 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Comparative Risk Analysis: an Informal Survey of Experts [PDF]

, 1997
Hammitt, James
core   +1 more source